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Morphine

In Vitro Substrates

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Km (μM)	Cell System	Reference
SLC22A1	OCT1	3.4	HEK293-OCT1	Tzvetkov, 2013
SLC22A2	OCT2	ND	HEK293-OCT2	Zhu, 2018

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Inhibitor	IC50 (μM)	Substrate used	Cell System	Reference
SLC22A1	OCT1	Morphine	4.2	1-methyl-4-phenylpyridinium (MPP+)	HEK293-OCT1	Tzvetkov, 2013
SLC22A1	OCT1	Morphine	28	4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+)	HEK293-OCT1	Ahlin, 2008
ABCB1	MDR1, P-gp	Morphine	>50	Calcein AM	MDR1 expressing LLC-PK1 cells	Schwab, 2003
mouse_Abcb1a	Mdr, Pgp, Pgy, Mdr3, P-gp, Abcb4, Mdr1a	Morphine	>50	Calcein AM	Mouse mdr1a expressing LLC-PK1 cells	Schwab, 2003
mouse_Abcb1b	mdr, Mdr1, Pgy1, Abcb1, Mdr1b, Pgy-1	Morphine	>50	Calcein AM	Mouse mdr1b expressing LLC-PK1 cells	Schwab, 2003

No drug-drug interaction information.