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Mitoxantrone

In Vitro Substrates

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Km (μM)	Cell System	Reference
ABCG2	BCRP, MXR	7	ATP hydrolysis assay of BCRP-expressing Sf9 vesicles	Ozvegy, 2001

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Inhibitor	IC50 (μM)	Substrate used	Cell System	Reference
SLC22A1	OCT1	Mitoxantrone	43.9	4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+)	HEK293-OCT1	Wittwer, 2013
SLC22A3	OCT3	Mitoxantrone	60.5	4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+)	HEK293-OCT3	Wittwer, 2013
SLC22A2	OCT2	Mitoxantrone	73.3	4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+)	HEK293-OCT2	Wittwer, 2013
SLC47A1	MATE1	Mitoxantrone	0.53	4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+)	HEK293-MATE1	Wittwer, 2013
SLC47A2	MATE2K	Mitoxantrone	0.53	4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+)	HEK293-MATE2K	Wittwer, 2013
SLC47A2	MATE2K	Mitoxantrone	0.83	4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+)	HEK293-MATE2K	Wittwer, 2013
SLC47A1	MATE1	Mitoxantrone	4.4	Metformin	HeLa-MATE1	Meyer, 2010
SLC47A1	MATE1	Mitoxantrone	0.19	Metformin	MDCK2- MATE1	Wittwer, 2013
SLC47A1	MATE1	Mitoxantrone	0.4	Metformin	HEK293-MATE1	Wittwer, 2013
SLC22A4	OCTN1	Mitoxantrone	0.00275	Tetraethylammonium	KB-3-3-hOCTN1	Okabe, 2008
SLC47A1	MATE1	Mitoxantrone	5.2	Tetraethylammonium	HeLa-MATE1	Meyer, 2010

No drug-drug interaction information.