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Metoprolol

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

No substrate information.


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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
SLC22A1 OCT1 Metoprolol 268 1-methyl-4-phenylpyridinium (MPP+) HEK293-OCT1 Umehara, 2008
SLC22A1 OCT1 Metoprolol 52.6 1-methyl-4-phenylpyridinium (MPP+) MDCK-OCT1 Grube, 2011
ABCB1 MDR1, P-gp Metoprolol 1440 Calcein AM Caco-2 cells Eneroth, 2001
ABCC2 MRP2, cMOAT Metoprolol >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC3 MRP3 Metoprolol >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC4 MRP4 Metoprolol >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCB11 BSEP Metoprolol >133 Taurocholate Sf9 cell membrane vesicles Morgan, 2013
ABCB1 MDR1, P-gp Metoprolol 1300 Verapamil Caco-2 cells Doppenshmitt, 1998

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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