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Memantine
Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions
* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
| Transporter |
Synonyms |
Km (μM) |
Cell System |
Reference |
| SLC22A2 |
OCT2 |
34 |
HEK293-OCT2 |
Busch, 1998 |
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* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
| Transporter |
Synonyms |
Inhibitor |
IC50 (μM) |
Ki (μM) |
Substrate used |
Cell System |
Reference |
| SLC22A1 |
OCT1 |
Memantine |
27 |
|
4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+) |
HEK293-OCT1 |
Ahlin, 2008 |
| SLC22A1 |
OCT1 |
Memantine |
|
3.7 |
N-methylpyridinium |
HEK293-OCT1 |
Amphoux, 2006 |
| SLC22A2 |
OCT2 |
Memantine |
|
7.3 |
N-methylpyridinium |
HEK293-OCT2 |
Amphoux, 2006 |
| SLC22A3 |
OCT3 |
Memantine |
|
236 |
N-methylpyridinium |
HEK293-OCT3 |
Amphoux, 2006 |
| rat_Slc22a1 |
Oct1, Orct1, Roct1 |
Memantine |
|
1.7 |
N-methylpyridinium |
HEK293-rOCT1 |
Amphoux, 2006 |
| rat_Slc22a2 |
OCT2, OCT2r, rOCT2 |
Memantine |
|
73 |
N-methylpyridinium |
HEK293-rOCT2 |
Amphoux, 2006 |
| rat_Slc22a3 |
Oct3 |
Memantine |
|
295 |
N-methylpyridinium |
HEK293-rOCT3 |
Amphoux, 2006 |
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No drug-drug interaction information.
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