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Mefenamic acid

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

No substrate information.


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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
SLC22A6 OAT1 Mefenamic acid 1.085 6-CF COS-7-OAT1 Duan, 2012
SLC22A8 OAT3 Mefenamic acid 1.75 6-CF COS-7-OAT3 Duan, 2012
ABCC2 MRP2, cMOAT Mefenamic acid >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC3 MRP3 Mefenamic acid >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC4 MRP4 Mefenamic acid >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
SLC22A11 OAT4 Mefenamic acid 61.7 Estrone sulfate S2-OAT4 Khamdang, 2002
SLC22A8 OAT3 Mefenamic acid 0.78 Estrone sulfate S2-OAT3 Khamdang, 2002
SLC22A6 OAT1 Mefenamic acid 0.83 Para-aminohippurate S2-OAT1 Khamdang, 2002
SLC22A7 OAT2 Mefenamic acid 21.7 Prostaglandin F2-alpha S2-OAT2 Khamdang, 2002
ABCB11 BSEP Mefenamic acid >133 Taurocholate Sf9 cell membrane vesicles Morgan, 2013

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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