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Lovastatin Lactone

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

No substrate information.


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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
ABCB1 MDR1, P-gp Lovastatin Lactone 10 Calcein AM MDR1 expressing MDCK cells Chen, 2005
SLCO1B1 OATP1B1, OATP-C, OATP2, LST-1 Lovastatin Lactone 28 Estradiol-17beta-glucuronide HEK-OATP1B1 Chen, 2005
ABCB1 MDR1, P-gp Lovastatin Lactone 114.4 Rhodamine 123 NIH-3T3-G185 cells Wang, 2001

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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