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Linezolid

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

No substrate information.


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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
ABCC2 MRP2, cMOAT Linezolid >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC3 MRP3 Linezolid >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC4 MRP4 Linezolid >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
SLCO1B1 OATP1B1, OATP-C, OATP2, LST-1 Linezolid 65.9 Estrone sulfate HEK-OATP1B1 Parvez, 2016
SLC22A8 OAT3 Linezolid 21.9 Estrone sulfate HEK293-OAT3 Parvez, 2016
SLC22A6 OAT1 Linezolid 31.1 PAH HEK293-OAT1 Parvez, 2016
SLC22A8 OAT3 Linezolid 53 Relebactam MDCKII-OAT3 Chan, 2019
ABCB11 BSEP Linezolid >133 Taurocholate Sf9 cell membrane vesicles Morgan, 2013

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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