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Levothyroxine

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

No substrate information.


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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
SLCO1B1 OATP1B1, OATP-C, OATP2, LST-1 Levothyroxine 0.88 Cerivastatin HEK-OATP1B1 Tamraz, 2013
SLCO2B1 OATP2B1, OATP-B Levothyroxine 10.4 Dibromofluorescein HEK293-OATP2B1 Unger, 2020
SLCO1B1 OATP1B1, OATP-C, OATP2, LST-1 Levothyroxine 2.04 Estrone sulfate HEK-OATP1B1 Tamraz, 2013

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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