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Leflunomide

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

No substrate information.


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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
SLC22A8 OAT3 Leflunomide 4.1 6-CF HEK293-OAT3 Liao, 2020
ABCC2 MRP2, cMOAT Leflunomide >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC3 MRP3 Leflunomide >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC4 MRP4 Leflunomide >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCG2 BCRP, MXR Leflunomide 1.86 Methotrexate BCRP membrane vesicles Kis, 2009
ABCB11 BSEP Leflunomide >133 Taurocholate Sf9 cell membrane vesicles Morgan, 2013

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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