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Lapatinib

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

No substrate information.


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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
SLC22A1 OCT1 Lapatinib 96 1-methyl-4-phenylpyridinium (MPP+) HEK293-OCT1 Johnston, 2014
ABCG2 BCRP, MXR Lapatinib 0.025 Cimetidine polarized MDCKII-BCRP Lee, 2015
ABCC2 MRP2, cMOAT Lapatinib >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC3 MRP3 Lapatinib >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC4 MRP4 Lapatinib >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
SLC22A1 OCT1 Lapatinib >30 Metformin HEK293-OCT1 Minematsu, 2011
ABCB11 BSEP Lapatinib 6.49 Taurocholate Sf9 cell membrane vesicles Morgan, 2013

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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