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L-carnitine

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Km (μM) Cell System Reference
SLC22A5 OCTN2 4.3 HEK293-OCTN2 Ohashi, 1999
SLC22A5 OCTN2 3.5 HeLa-OCTN2 Ganapathy, 2000
SLC22A5 OCTN2 4.8 OCTN2-expressing oocytes Wagner, 2000
SLC22A4 OCTN1 571 HEK293-hOCTN1 Peltekova, 2004
SLC22A5 OCTN2 23.6 primary epididymal spermatozoa Kobayashi, 2007
SLC22A5 OCTN2 29 TR-iBRB2 cells Tachikawa, 2010

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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
SLC22A5 OCTN2 L-carnitine 11.8 L-carnitine HRPE-hOCTN2 Wu, 1999
SLC22A5 OCTN2 L-carnitine 3.7 L-carnitine BeWo cells expressing OCTN2 Rytting, 2005

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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