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Ketoprofen
Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions
No substrate information.
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* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
| Transporter |
Synonyms |
Inhibitor |
IC50 (μM) |
Ki (μM) |
Substrate used |
Cell System |
Reference |
| SLC22A6 |
OAT1 |
Ketoprofen |
1.4 |
|
6-carboxyfluorescein |
CHO-OAT1 |
Cihlar, 2000 |
| SLC22A8 |
OAT3 |
Ketoprofen |
1.61 |
|
6-carboxyfluorescein |
HEK293-OAT3 |
Zou, 2021 |
| SLC22A6 |
OAT1 |
Ketoprofen |
1.73 |
|
6-carboxyfluorescein |
HEK293-OAT1 |
Zou, 2021 |
| SLC22A6 |
OAT1 |
Ketoprofen |
1.3 |
|
Adefovir |
CHO-OAT1 |
Mulato, 2000 |
| SLC22A11 |
OAT4 |
Ketoprofen |
70.3 |
|
Estrone sulfate |
S2-OAT4 |
Khamdang, 2002 |
| SLC22A8 |
OAT3 |
Ketoprofen |
5.98 |
|
Estrone sulfate |
S2-OAT3 |
Khamdang, 2002 |
| ABCC2 |
MRP2, cMOAT |
Ketoprofen |
1.4 |
|
Methotrexate |
MRP2-expressing HEK293 vesicles |
El-Sheikh, 2007 |
| ABCC4 |
MRP4 |
Ketoprofen |
11.9 |
|
Methotrexate |
MRP4-expressing HEK293 vesicles |
El-Sheikh, 2007 |
| SLC22A6 |
OAT1 |
Ketoprofen |
4.34 |
|
Para-aminohippurate |
S2-OAT1 |
Khamdang, 2002 |
| SLC22A7 |
OAT2 |
Ketoprofen |
400 |
|
Prostaglandin F2-alpha |
S2-OAT2 |
Khamdang, 2002 |
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No drug-drug interaction information.
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