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Ketamine

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

No substrate information.


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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
ABCC2 MRP2, cMOAT Ketamine >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC3 MRP3 Ketamine >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC4 MRP4 Ketamine >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
SLC22A1 OCT1 Ketamine 114.5 N-methylpyridinium HEK293-OCT1 Amphoux, 2006
SLC22A2 OCT2 Ketamine 22.7 N-methylpyridinium HEK293-OCT2 Amphoux, 2006
SLC22A3 OCT3 Ketamine 225.7 N-methylpyridinium HEK293-OCT3 Amphoux, 2006
rat_Slc22a1 Oct1, Orct1, Roct1 Ketamine 4.7 N-methylpyridinium HEK293-rOCT1 Amphoux, 2006
rat_Slc22a2 OCT2, OCT2r, rOCT2 Ketamine 207 N-methylpyridinium HEK293-rOCT2 Amphoux, 2006
rat_Slc22a3 Oct3 Ketamine 65.7 N-methylpyridinium HEK293-rOCT3 Amphoux, 2006
ABCB11 BSEP Ketamine >133 Taurocholate Sf9 cell membrane vesicles Morgan, 2013

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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