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Ivermectin

In Vitro Substrates

No substrate information.

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Inhibitor	IC50 (μM)	Ki (μM)	Substrate used	Cell System	Reference
ABCC3	MRP3	Ivermectin	-	2.7	Benzbromarone	Sf9 cell membranes	Lespine, 2006
ABCB1	MDR1, P-gp	Ivermectin	9		Calcein AM	Caco-2 cells	Eneroth, 2001
ABCB1	MDR1, P-gp	Ivermectin	0.1		Calcein AM	MDR1 expressing LLC-PK1 cells	Schwab, 2003
mouse_Abcb1a	Mdr, Pgp, Pgy, Mdr3, P-gp, Abcb4, Mdr1a	Ivermectin	0.5		Calcein AM	Mouse mdr1a expressing LLC-PK1 cells	Schwab, 2003
mouse_Abcb1b	mdr, Mdr1, Pgy1, Abcb1, Mdr1b, Pgy-1	Ivermectin	0.5		Calcein AM	Mouse mdr1b expressing LLC-PK1 cells	Schwab, 2003
ABCC1	MRP1	Ivermectin	3.8		Calcein AM	HL60 cells	Lespine, 2006
ABCB1	MDR1, P-gp	Ivermectin	10.9		Doxorubicin	B16/F10 cells	Bain, 1996
ABCG2	BCRP, MXR	Ivermectin	2.8	1.4	Estrone sulfate	BCRP membrane vesicles	Jani, 2011
ABCC1	MRP1	Ivermectin	-	0.5	N-ethylmaleimide-GS	Sf9 cell membranes	Lespine, 2006
ABCC2	MRP2, cMOAT	Ivermectin	-	3.6	Probenecid	Sf9 cell membranes	Lespine, 2006
ABCB1	MDR1, P-gp	Ivermectin	0.1		Rhodamine 123	Caco-2 cells	Griffin, 2005
mouse_Abcb1a	Mdr, Pgp, Pgy, Mdr3, P-gp, Abcb4, Mdr1a	Ivermectin	0.4		Rhodamine 123	LLC-PK1 cells	Lespine, 2006
ABCB1	MDR1, P-gp	Ivermectin	-	0.06	Verapamil	Sf9 cell membranes	Lespine, 2006

No drug-drug interaction information.