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Ipratropium

In Vitro Substrates

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Km (μM)	Cell System	Reference
SLC22A5	OCTN2	53	HEK293-OCTN2	Nakamura, 2010
SLC22A4	OCTN1	444	HEK293-OCTN1	Nakamura, 2010
SLC22A1	OCT1	9	HEK293-OCT1	Hendrickx, 2013
SLC22A1	OCT1	9	HEK293-OCT1	Hendrickx, 2013
SLC22A1	OCT1	14	HEK293-OCT1	Chen, 2017
SLC47A1	MATE1	44.8	HEK293-MATE1	Chen, 2017
SLC47A2	MATE2K	95.7	HEK293-MATE2K	Chen, 2017

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Inhibitor	IC50 (μM)	Substrate used	Cell System	Reference
SLC22A1	OCT1	Ipratropium	17	1-methyl-4-phenylpyridinium (MPP+)	HEK293-OCT1	Chen, 2017
SLC47A1	MATE1	Ipratropium	30.5	1-methyl-4-phenylpyridinium (MPP+)	HEK293-MATE1	Chen, 2017
SLC47A2	MATE2K	Ipratropium	62.8	1-methyl-4-phenylpyridinium (MPP+)	HEK293-MATE2K	Chen, 2017
ABCC2	MRP2, cMOAT	Ipratropium	>133	Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
ABCC3	MRP3	Ipratropium	>133	Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
ABCC4	MRP4	Ipratropium	>133	Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
SLC22A2	OCT2	Ipratropium	15	N-methylpyridinium	HEK293-OCT2	Zolk, 2009
SLC22A2	OCT2	Ipratropium	0.17	NBD-MTMA	CHO-OCT2	Belzer, 2013
ABCB11	BSEP	Ipratropium	>133	Taurocholate	Sf9 cell membrane vesicles	Morgan, 2013

No drug-drug interaction information.