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Ibuprofen
Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions
No substrate information.
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* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
| Transporter |
Synonyms |
Inhibitor |
IC50 (μM) |
Ki (μM) |
Substrate used |
Cell System |
Reference |
| SLC22A6 |
OAT1 |
Ibuprofen |
8 |
|
Adefovir |
CHO-OAT1 |
Mulato, 2000 |
| SLC22A8 |
OAT3 |
Ibuprofen |
4.46 |
|
Baricitinib |
HEK-PEAK-OAT3 |
Posada, 2017 |
| SLC22A11 |
OAT4 |
Ibuprofen |
103 |
|
Estrone sulfate |
S2-OAT4 |
Khamdang, 2002 |
| SLC22A8 |
OAT3 |
Ibuprofen |
6 |
|
Estrone sulfate |
S2-OAT3 |
Khamdang, 2002 |
| SLC22A8 |
OAT3 |
Ibuprofen |
6.1 |
|
Isoniazid |
HEK293-OAT3 |
Parvez, 2018 |
| SLC22A6 |
OAT1 |
Ibuprofen |
55.6 |
|
Para-aminohippurate |
S2-OAT1 |
Khamdang, 2002 |
| SLC22A6 |
OAT1 |
Ibuprofen |
5.1 |
|
Para-Aminosalicylic acid (PAS) |
HEK293-OAT1 |
Parvez, 2017 |
| SLC22A8 |
OAT3 |
Ibuprofen |
1.98 |
|
Para-Aminosalicylic acid (PAS) |
HEK293-OAT3 |
Parvez, 2017 |
| SLC22A8 |
OAT3 |
Ibuprofen |
27.9 |
|
Pemetrexed |
HEK-OAT3 |
Kurata, 2014 |
| SLC22A7 |
OAT2 |
Ibuprofen |
692 |
|
Prostaglandin F2-alpha |
S2-OAT2 |
Khamdang, 2002 |
| SLC22A8 |
OAT3 |
Ibuprofen |
3.7 |
|
Sitagliptin |
CHO-OAT3 |
Chu, 2007 |
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No drug-drug interaction information.
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