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Hydrochlorothiazide

In Vitro Substrates

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Km (μM)	Cell System	Reference
SLC22A6	OAT1	112	HEK293-OAT1	Yin, 2019
SLC22A8	OAT3	134	HEK293-OAT3	Yin, 2019
SLC47A2	MATE2K	681	HEK293-MATE2K	Yin, 2019
SLC22A2	OCT2	812	HEK293-OCT2	Yin, 2019

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Inhibitor	IC50 (μM)	Ki (μM)	Substrate used	Cell System	Reference
ABCC2	MRP2, cMOAT	Hydrochlorothiazide	>133		Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
ABCC3	MRP3	Hydrochlorothiazide	>133		Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
ABCC4	MRP4	Hydrochlorothiazide	>133		Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
SLC22A8	OAT3	Hydrochlorothiazide	942		Estrone sulfate	S2-OAT3	Hasannejad, 2004
SLC22A8	OAT3	Hydrochlorothiazide	213		Estrone sulfate	HEK293-OAT3	Yin, 2019
SLC22A5	OCTN2	Hydrochlorothiazide		4110	L-carnitine	MDCKII-hOCTN2	Diao, 2009
SLC22A6	OAT1	Hydrochlorothiazide	126		PAH	HEK293-OAT1	Yin, 2019
SLC22A6	OAT1	Hydrochlorothiazide	67.3		Para-aminohippurate	S2-OAT1	Hasannejad, 2004
SLC22A7	OAT2	Hydrochlorothiazide	1023		Prostaglandin F2-alpha	S2-OAT2	Hasannejad, 2004
ABCB11	BSEP	Hydrochlorothiazide	>133		Taurocholate	Sf9 cell membrane vesicles	Morgan, 2013

No drug-drug interaction information.