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Haloperidol

In Vitro Substrates

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Km (μM)	Cell System	Reference
ABCB1	MDR1, P-gp	33	MDR1-expressing insect vesicles	Boulton, 2002

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Inhibitor	IC50 (μM)	Ki (μM)	Substrate used	Cell System	Reference
ABCC2	MRP2, cMOAT	Haloperidol	>133		Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
ABCC3	MRP3	Haloperidol	>133		Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
ABCC4	MRP4	Haloperidol	>133		Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
ABCB11	BSEP	Haloperidol	>133		Taurocholate	Sf9 cell membrane vesicles	Morgan, 2013
SLC22A2	OCT2	Haloperidol	32.5	51.6	Tetraethylammonium	S2-OCT2	Chiba, 2013
ABCB1	MDR1, P-gp	Haloperidol	5.3		Verapamil	Caco-2 cells	Doppenshmitt, 1998

No drug-drug interaction information.