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Gemifloxacin

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Km (μM) Cell System Reference
ABCG2 BCRP, MXR 145.69 MDCK-transfected cells Jin, 2013

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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
ABCC2 MRP2, cMOAT Gemifloxacin 16 Erythromycin MDCKII-MRP2 Vadlapatla, 2011
ABCC4 MRP4 Gemifloxacin 73.2 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC2 MRP2, cMOAT Gemifloxacin >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC3 MRP3 Gemifloxacin >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCB11 BSEP Gemifloxacin >133 Taurocholate Sf9 cell membrane vesicles Morgan, 2013

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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