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Fluoxetine

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

No substrate information.


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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
SLC22A2 OCT2 Fluoxetine 56.7 1-methyl-4-phenylpyridinium (MPP+) CHO-OCT2 Sandoval, 2018
SLC22A2 OCT2 Fluoxetine 16.7 4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+) CHO-OCT2 Sandoval, 2018
ABCC2 MRP2, cMOAT Fluoxetine >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC3 MRP3 Fluoxetine >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC4 MRP4 Fluoxetine >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
SLC22A2 OCT2 Fluoxetine 18.6 Metformin CHO-OCT2 Sandoval, 2018
SLC22A1 OCT1 Fluoxetine 6 Morphine HEK293-OCT1 Tzvetkov, 2013
SLC22A1 OCT1 Fluoxetine 9.1 Morphine HEK293-OCT1 Zhu, 2018
SLC22A2 OCT2 Fluoxetine 20.1 NBD-MTMA CHO-OCT2 Sandoval, 2018
SLC22A1 OCT1 Fluoxetine 6.2 Serotonin HEK293-OCT1 Boxberger, 2014
ABCB11 BSEP Fluoxetine >133 Taurocholate Sf9 cell membrane vesicles Morgan, 2013
SLC22A2 OCT2 Fluoxetine 36 Tetraethylammonium CHO-OCT2 Sandoval, 2018

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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