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Flecainide

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

No substrate information.


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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
SLC22A1 OCT1 Flecainide 41.5 1-methyl-4-phenylpyridinium (MPP+) HEK293-OCT1 Umehara, 2008
SLC22A1 OCT1 Flecainide 2.5 1-methyl-4-phenylpyridinium (MPP+) MDCK-OCT1 Grube, 2011
SLC22A2 OCT2 Flecainide 191 N-methylpyridinium HEK293-OCT2 Zolk, 2009
SLC22A2 OCT2 Flecainide 234 NBD-MTMA CHO-OCT2 Belzer, 2013
SLC22A4 OCTN1 Flecainide 176 Tetraethylammonium MDCKII-hOCTN1 Grube, 2011

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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