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Felodipine

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

No substrate information.


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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
ABCB1 MDR1, P-gp Felodipine 26.3 Daunorubicin NIH-3T3-G185 cells Wang, 2001
SLCO2B1 OATP2B1, OATP-B Felodipine 3.5 Dibromofluorescein HEK293-OATP2B1 Unger, 2020
ABCC2 MRP2, cMOAT Felodipine >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC3 MRP3 Felodipine >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC4 MRP4 Felodipine >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCB1 MDR1, P-gp Felodipine 32.3 LDS-751 NIH-3T3-G185 cells Wang, 2001
ABCB1 MDR1, P-gp Felodipine 60 Rhodamine 123 NIH-3T3-G185 cells Wang, 2001
ABCB11 BSEP Felodipine 69.7 Taurocholate Sf9 cell membrane vesicles Morgan, 2013

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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