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Etoposide

In Vitro Substrates

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Km (μM)	Cell System	Reference
ABCB1	MDR1, P-gp	255	MDCK II-MDR1	Guo, 2002
ABCC2	MRP2, cMOAT	617	MDCK II-MRP2	Guo, 2002
ABCB1	MDR1, P-gp	461	Caco-2	Troutman, 2003
SLC22A5	OCTN2	150	LLC-PK1-hOCTN2	Hu, 2012

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Inhibitor	IC50 (μM)	Ki (μM)	Substrate used	Cell System	Reference
ABCB1	MDR1, P-gp	Etoposide	>50		Calcein AM	MDR1 expressing LLC-PK1 cells	Schwab, 2003
mouse_Abcb1a	Mdr, Pgp, Pgy, Mdr3, P-gp, Abcb4, Mdr1a	Etoposide	>50		Calcein AM	Mouse mdr1a expressing LLC-PK1 cells	Schwab, 2003
mouse_Abcb1b	mdr, Mdr1, Pgy1, Abcb1, Mdr1b, Pgy-1	Etoposide	>50		Calcein AM	Mouse mdr1b expressing LLC-PK1 cells	Schwab, 2003
ABCB1	MDR1, P-gp	Etoposide		768	Digoxin	MDR1-expressing MDCK cells	Tang, 2002
ABCC2	MRP2, cMOAT	Etoposide	>133		Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
ABCC3	MRP3	Etoposide	>133		Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
ABCC4	MRP4	Etoposide	>133		Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
SLC22A5	OCTN2	Etoposide	55		L-carnitine	LLC-PK1-hOCTN2	Hu, 2012
ABCB1	MDR1, P-gp	Etoposide		276	Paclitaxel	MDR1-expressing Caco-2 cells	Gao, 2001
ABCB11	BSEP	Etoposide	>133		Taurocholate	Sf9 cell membrane vesicles	Morgan, 2013
ABCC2	MRP2, cMOAT	Etoposide		756	Vinblastine	MDCK II-MRP2	Tang, 2002

No drug-drug interaction information.