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Ethambutol

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Km (μM) Cell System Reference
SLC22A2 OCT2 314 HEK293-OCT2 Te, 2016
SLC22A2 OCT2 212 HEK293-OCT2 Parvez, 2018
SLC22A4 OCTN1 336.8 HEK293-hOCTN1 Parvez, 2018
SLC22A5 OCTN2 455 HEK293-hOCTN2 Parvez, 2018
SLC22A1 OCT1 526 HEK293-OCT1 Parvez, 2018

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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
SLC22A1 OCT1 Ethambutol >100 1-methyl-4-phenylpyridinium (MPP+) HEK293-OCT1 Parvez, 2016
SLC22A2 OCT2 Ethambutol 229 1-methyl-4-phenylpyridinium (MPP+) HEK293-OCT2 Parvez, 2016
SLCO1B1 OATP1B1, OATP-C, OATP2, LST-1 Ethambutol 57.6 Estrone sulfate HEK-OATP1B1 Parvez, 2016
SLC22A2 OCT2 Ethambutol 189.2 Metformin HEK293-OCT2 Parvez, 2016

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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