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Ethacrynic acid

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

No substrate information.


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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
SLC22A8 OAT3 Ethacrynic acid 0.662 6-CF COS-7-OAT3 Duan, 2012
ABCC2 MRP2, cMOAT Ethacrynic acid 3.85 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC3 MRP3 Ethacrynic acid 95.9 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC4 MRP4 Ethacrynic acid >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
SLC22A11 OAT4 Ethacrynic acid 8.76 Estrone sulfate S2-OAT4 Hasannejad, 2004
SLC22A8 OAT3 Ethacrynic acid 0.58 Estrone sulfate S2-OAT3 Hasannejad, 2004
SLC22A6 OAT1 Ethacrynic acid 29.6 Para-aminohippurate S2-OAT1 Hasannejad, 2004
SLC22A7 OAT2 Ethacrynic acid 121 Prostaglandin F2-alpha S2-OAT2 Hasannejad, 2004
ABCB11 BSEP Ethacrynic acid >133 Taurocholate Sf9 cell membrane vesicles Morgan, 2013

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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