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Emetine

In Vitro Substrates

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Km (μM)	Cell System	Reference
ABCB1	MDR1, P-gp	6	MDR1-containing proteoliposomes	Borgnia, 1996

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Inhibitor	IC50 (μM)	Substrate used	Cell System	Reference
ABCB1	MDR1, P-gp	Emetine	35.1	Calcein AM	NIH-3T3-G185 cells	Wang, 2001
ABCB1	MDR1, P-gp	Emetine	9.2	Daunorubicin	NIH-3T3-G185 cells	Wang, 2001
ABCC2	MRP2, cMOAT	Emetine	>133	Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
ABCC3	MRP3	Emetine	>133	Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
ABCC4	MRP4	Emetine	>133	Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
ABCB1	MDR1, P-gp	Emetine	130.3	Fluo-3	NIH-3T3-G185 cells	Wang, 2001
ABCB1	MDR1, P-gp	Emetine	115.6	JC-1	NIH-3T3-G185 cells	Wang, 2001
SLC22A5	OCTN2	Emetine	4.2	L-carnitine	OCTN2-expressing oocytes	Wagner, 2000
ABCB1	MDR1, P-gp	Emetine	2.4	LDS-751	NIH-3T3-G185 cells	Wang, 2001
ABCB1	MDR1, P-gp	Emetine	9.6	Rhodamine 123	NIH-3T3-G185 cells	Wang, 2001
ABCB11	BSEP	Emetine	>133	Taurocholate	Sf9 cell membrane vesicles	Morgan, 2013
ABCB1	MDR1, P-gp	Emetine	207.1	Tetramethylrosamine	NIH-3T3-G185 cells	Wang, 2001

No drug-drug interaction information.