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Dolutegravir

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

No substrate information.


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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
ABCC2 MRP2, cMOAT Dolutegravir 90 Estradiol-17beta-glucuronide MRP2-expressing sf9 vesicles Reese, 2013
ABCC2 MRP2, cMOAT Dolutegravir 100 Estradiol-17beta-glucuronide MRP2-expressing sf9 vesicles Reese, 2013
SLC22A2 OCT2 Dolutegravir 1.9 Metformin MDCKII_OCT2 Reese, 2013
SLC47A1 MATE1 Dolutegravir 4.7 Tetraethylammonium CHO-MATE1 Lepist, 2014

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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