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Disopyramide

In Vitro Substrates

No substrate information.

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Inhibitor	IC50 (μM)	Ki (μM)	Substrate used	Cell System	Reference
SLC22A1	OCT1	Disopyramide	81.7		4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+)	HEK293-OCT1	Ahlin, 2008
SLC22A1	OCT1	Disopyramide	>100		4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+)	HEK293-OCT1	Kido, 2011
SLC47A1	MATE1	Disopyramide	66		4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+)	HEK293-MATE1	Kido, 2011
SLC47A2	MATE2K	Disopyramide	100		4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+)	HEK293-MATE2K	Kido, 2011
ABCC2	MRP2, cMOAT	Disopyramide	>133		Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
ABCC3	MRP3	Disopyramide	>133		Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
ABCC4	MRP4	Disopyramide	>133		Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
SLC22A2	OCT2	Disopyramide	324		N-methylpyridinium	HEK293-OCT2	Zolk, 2009
SLC22A2	OCT2	Disopyramide	39		NBD-MTMA	CHO-OCT2	Belzer, 2013
ABCB11	BSEP	Disopyramide	>133		Taurocholate	Sf9 cell membrane vesicles	Morgan, 2013
SLC47A1	MATE1	Disopyramide		83.8	Tetraethylammonium	HEK293-MATE1	Tsuda, 2009
SLC47A2	MATE2K	Disopyramide		291.6	Tetraethylammonium	HEK293-MATE2	Tsuda, 2009

No drug-drug interaction information.