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Diphenhydramine

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

No substrate information.


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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
ABCC2 MRP2, cMOAT Diphenhydramine >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC3 MRP3 Diphenhydramine >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC4 MRP4 Diphenhydramine >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
SLC22A1 OCT1 Diphenhydramine 3.4 N-methylpyridinium HEK293-OCT1 Muller, 2005
SLC22A2 OCT2 Diphenhydramine 15 N-methylpyridinium HEK293-OCT2 Muller, 2005
SLC22A3 OCT3 Diphenhydramine 695 N-methylpyridinium CHO-OCT3 Muller, 2005
SLC22A2 OCT2 Diphenhydramine 21 N-methylpyridinium HEK293-OCT2 Zolk, 2009
SLC22A2 OCT2 Diphenhydramine 5.8 NBD-MTMA CHO-OCT2 Belzer, 2013
SLC22A1 OCT1 Diphenhydramine 4.1 Serotonin HEK293-OCT1 Boxberger, 2014
ABCB11 BSEP Diphenhydramine >133 Taurocholate Sf9 cell membrane vesicles Morgan, 2013
SLC47A1 MATE1 Diphenhydramine 87 Tetraethylammonium HEK293-MATE1 Tsuda, 2009
SLC47A2 MATE2K Diphenhydramine 266.5 Tetraethylammonium HEK293-MATE2 Tsuda, 2009

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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