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Dihydroergotamine

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

No substrate information.


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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
SLC22A2 OCT2 Dihydroergotamine 49.9 4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+) HEK293-OCT2 Wittwer, 2013
SLC47A1 MATE1 Dihydroergotamine 2.8 4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+) HEK293-MATE1 Wittwer, 2013
SLC47A2 MATE2K Dihydroergotamine 12.6 4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+) HEK293-MATE2K Wittwer, 2013
ABCB1 MDR1, P-gp Dihydroergotamine 1000 Calcein AM MDR1-expressing LLC-PK1 cells Ekins, 2002
ABCB1 MDR1, P-gp Dihydroergotamine 119.94 Vinblastine MDR1-expressing LLC-PK1 cells Ekins, 2002

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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