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Diclofenac
Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions
No substrate information.
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* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
| Transporter |
Synonyms |
Inhibitor |
IC50 (μM) |
Ki (μM) |
Substrate used |
Cell System |
Reference |
| SLC22A8 |
OAT3 |
Diclofenac |
0.62 |
|
6-carboxyfluorescein |
HEK293-OAT3 |
Zou, 2021 |
| SLC22A6 |
OAT1 |
Diclofenac |
1.67 |
|
6-carboxyfluorescein |
HEK293-OAT1 |
Zou, 2021 |
| SLC22A6 |
OAT1 |
Diclofenac |
4 |
|
Adefovir |
CHO-OAT1 |
Mulato, 2000 |
| SLC22A8 |
OAT3 |
Diclofenac |
3.7 |
|
Baricitinib |
HEK-PEAK-OAT3 |
Posada, 2017 |
| SLC22A11 |
OAT4 |
Diclofenac |
34.5 |
|
Estrone sulfate |
S2-OAT4 |
Khamdang, 2002 |
| SLC22A8 |
OAT3 |
Diclofenac |
7.78 |
|
Estrone sulfate |
S2-OAT3 |
Khamdang, 2002 |
| ABCC4 |
MRP4 |
Diclofenac |
0.006 |
|
Methotrexate |
MRP4-expressing HEK293 vesicles |
El-Sheikh, 2007 |
| SLC22A6 |
OAT1 |
Diclofenac |
4.46 |
|
Para-aminohippurate |
S2-OAT1 |
Khamdang, 2002 |
| SLC22A6 |
OAT1 |
Diclofenac |
1.8 |
|
Para-Aminosalicylic acid (PAS) |
HEK293-OAT1 |
Parvez, 2017 |
| SLC22A8 |
OAT3 |
Diclofenac |
2 |
|
Para-Aminosalicylic acid (PAS) |
HEK293-OAT3 |
Parvez, 2017 |
| SLC22A7 |
OAT2 |
Diclofenac |
14.3 |
|
Prostaglandin F2-alpha |
S2-OAT2 |
Khamdang, 2002 |
| ABCG2 |
BCRP, MXR |
Diclofenac |
19.8 |
|
Rosuvastatin |
polarized Caco-2 monolayer |
Elsby, 2016 |
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No drug-drug interaction information.
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