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Desipramine

In Vitro Substrates

No substrate information.

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Inhibitor	IC50 (μM)	Ki (μM)	Substrate used	Cell System	Reference
SLC22A1	OCT1	Desipramine	56.8		4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+)	HEK293-OCT1	Ahlin, 2008
SLC22A1	OCT1	Desipramine	43.9		4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+)	HEK293-OCT1	Ahlin, 2010
SLC22A1	OCT1	Desipramine	9.18		4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+)	HEK293-OCT1	Chen, 2017
ABCC2	MRP2, cMOAT	Desipramine	>133		Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
ABCC3	MRP3	Desipramine	>133		Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
ABCC4	MRP4	Desipramine	>133		Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
SLC22A3	OCT3	Desipramine		14	N-methylpyridinium	HRPE-OCT3	Wu, 2000
ABCB11	BSEP	Desipramine	>133		Taurocholate	Sf9 cell membrane vesicles	Morgan, 2013
SLC22A2	OCT2	Desipramine	16		Tetraethylammonium	OCT2-expressing oocytes	Gorboulev, 1997
SLC22A4	OCTN1	Desipramine	80		Tetraethylammonium	HRPE-rOCTN1	Wu, 2000
SLC47A1	MATE1	Desipramine		55.7	Tetraethylammonium	HEK293-MATE1	Tsuda, 2009
SLC47A2	MATE2K	Desipramine		283	Tetraethylammonium	HEK293-MATE2	Tsuda, 2009

No drug-drug interaction information.