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Dehydroepiandrosterone sulfate

In Vitro Substrates

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Km (μM)	Cell System	Reference
SLC22A11	OAT4	0.63	OAT4-expressing oocytes	Cha, 2000
SLCO1B1	OATP1B1, OATP-C, OATP2, LST-1	21.5	HEK293-OATP1B1	Cui, 2001
SLCO1A2	OATP1A2, OATP-A	ND	OATP1A2-expressing oocytes	Kullak-Ublick, 2001
ABCC4	MRP4	1.9	MRP4-expressing Sf9 vesicles	Zelcer, 2003
OSTalpha	OSTA	ND	OSTalpha-OSTbeta expressing oocytes	Ballatori, 2005
OSTbeta	OSTB	ND	OSTalpha-OSTbeta expressing oocytes	Ballatori, 2005
ABCC2	MRP2, cMOAT	14.9	MRP2-expressing LLC-PK1 vesicles	Yamada, 2007
ABCC4	MRP4	26.2	MRP4-expressing LLC-PK1 vesicles	Yamada, 2007

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Inhibitor	IC50 (μM)	Ki (μM)	Substrate used	Cell System	Reference
ABCG2	BCRP, MXR	Dehydroepiandrosterone sulfate	55		Estrone sulfate	BCRP-expressing vesicles from mouse lymphoma (P388) cells	Suzuki, 2003

No drug-drug interaction information.