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Decynium-22

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

No substrate information.


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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
SLC22A1 OCT1 Decynium-22 0.98 1-methyl-4-phenylpyridinium (MPP+) HEK293-OCT1 Hayer-Zillgen, 2002
SLC22A2 OCT2 Decynium-22 0.0014 1-methyl-4-phenylpyridinium (MPP+) MDCK-OCT2 Sun, 2014
SLC22A2 OCT2 Decynium-22 0.005 Norepinephrine MDCK-OCT2 Sun, 2014
SLC22A2 OCT2 Decynium-22 0.0012 Serotonin MDCK-OCT2 Sun, 2014
SLC22A2 OCT2 Decynium-22 0.1 Tetraethylammonium OCT2-expressing oocytes Gorboulev, 1997
SLC22A1 OCT1 Decynium-22 2.73 Tetraethylammonium HeLa-OCT1 Zhang, 1998
SLC22A1 OCT1 Decynium-22 21.9 Tetraethylammonium OCT1-expressing oocytes Okuda, 1999
SLC22A2 OCT2 Decynium-22 13.8 Tetraethylammonium OCT2-expressing oocytes Okuda, 1999

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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