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Daunorubicin

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Km (μM) Cell System Reference
ABCG2 BCRP, MXR 2.5 ATP hydrolysis assay of BCRP-expressing Sf9 vesicles Ozvegy, 2001
ABCC6 MRP6 ND MRP6-expressing CHO vesicles Belinsky, 2002

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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
ABCB1 MDR1, P-gp Daunorubicin 111 Digoxin MDR1-expressing MDCK cells Tang, 2002
SLC22A5 OCTN2 Daunorubicin 502 L-carnitine MDCKII-hOCTN2 Diao, 2010
ABCB1 MDR1, P-gp Daunorubicin 2.5 Paclitaxel MDR1-expressing Caco-2 cells Gao, 2001
ABCC2 MRP2, cMOAT Daunorubicin 49.4 Vinblastine MDCK II-MRP2 Tang, 2002

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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