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Dasatinib

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

No substrate information.


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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
ABCC4 MRP4 Dasatinib 27.3 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
SLCO1B1 OATP1B1, OATP-C, OATP2, LST-1 Dasatinib 2.33 Estradiol-17beta-glucuronide HEK-OATP1B1 Pahwa, 2017
SLCO1B3 OATP1B3, OATP8 Dasatinib 5.76 Estradiol-17beta-glucuronide HEK293-OATP1B3 Pahwa, 2017
ABCC2 MRP2, cMOAT Dasatinib >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC3 MRP3 Dasatinib >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
SLC22A1 OCT1 Dasatinib 1.07 Metformin HEK293-OCT1 Minematsu, 2011
SLC47A1 MATE1 Dasatinib 0.8 Metformin HEK293-MATE1 Minematsu, 2011
SLC47A2 MATE2K Dasatinib 0.8 Metformin HEK293-MATE2K Minematsu, 2011
ABCB11 BSEP Dasatinib 13.1 Taurocholate Sf9 cell membrane vesicles Morgan, 2013

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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