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Darunavir

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

No substrate information.


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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
SLCO1B1 OATP1B1, OATP-C, OATP2, LST-1 Darunavir 3.5 3.1 Cholyl-glycylamido-fluorescein (CGamF) CHO-OATP1B1 Annaert, 2010
SLCO1B3 OATP1B3, OATP8 Darunavir 4.8 3.3 Cholyl-glycylamido-fluorescein (CGamF) CHO-OATP1B3 Annaert, 2010
SLCO2B1 OATP2B1, OATP-B Darunavir 26 Estrone sulfate MDCK II-OATP2B1 Kis, 2010
SLC22A8 OAT3 Darunavir 37.9 Estrone sulfate HEK293-OAT3 Yee, 2021
SLC22A1 OCT1 Darunavir 6 Metformin HEK293-OCT1 Yee, 2021
ABCG2 BCRP, MXR Darunavir 75 Rosuvastatin polarized Caco-2 monolayer Elsby, 2016
SLC22A1 OCT1 Darunavir 16 Tetraethylammonium KCL22-OCT1 Moss, 2015

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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