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Cyclic GMP

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Km (μM) Cell System Reference
ABCC5 MRP5 2.1 MRP5-expressing V79 vesicles Jedlitschky, 2000
ABCC4 MRP4 9.69 MRP4-expressing Sf9 vesicles Chen, 2001
SLC22A7 OAT2 88 HEK-OAT2 Cropp, 2008

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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
SLC22A7 OAT2 Cyclic GMP 93 2'-deoxyguanosine HEK-OAT2 Cropp, 2008
ABCC5 MRP5 Cyclic GMP 960 5-fluorodeoxyuridine monophosphate MRP5-expressing HEK293 vesicles Pratt, 2005
ABCC5 MRP5 Cyclic GMP 4855.5 Carboxydichlorofluorescein MRP5-expressing HEK293 vesicles Pratt, 2006

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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