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Colchicine

In Vitro Substrates

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Km (μM)	Cell System	Reference
ABCB1	MDR1, P-gp	45	MDR1-containing proteoliposomes	Ambudkar, 1992
ABCB1	MDR1, P-gp	1.33	MDR1-expressing CEM/VLB100 vesicles	Bebawy, 1999
ABCB1	MDR1, P-gp	1640	Caco-2	Troutman, 2003

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Inhibitor	IC50 (μM)	Substrate used	Cell System	Reference
ABCB1	MDR1, P-gp	Colchicine	>50	Calcein AM	MDR1 expressing LLC-PK1 cells	Schwab, 2003
mouse_Abcb1a	Mdr, Pgp, Pgy, Mdr3, P-gp, Abcb4, Mdr1a	Colchicine	>50	Calcein AM	Mouse mdr1a expressing LLC-PK1 cells	Schwab, 2003
mouse_Abcb1b	mdr, Mdr1, Pgy1, Abcb1, Mdr1b, Pgy-1	Colchicine	>50	Calcein AM	Mouse mdr1b expressing LLC-PK1 cells	Schwab, 2003
ABCC2	MRP2, cMOAT	Colchicine	>133	Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
ABCC3	MRP3	Colchicine	>133	Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
ABCC4	MRP4	Colchicine	>133	Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
SLC22A1	OCT1	Colchicine	29.7	Metformin	HEK293-OCT1	Yee, 2021
ABCB11	BSEP	Colchicine	>133	Taurocholate	Sf9 cell membrane vesicles	Morgan, 2013

No drug-drug interaction information.