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Clotrimazole

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

No substrate information.


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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
SLC22A1 OCT1 Clotrimazole 11.97 4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+) HEK293-OCT1 Chen, 2017
ABCB1 MDR1, P-gp Clotrimazole 44 Calcein AM MDR1-expressing LLC-PK1 cells Ekins, 2002
ABCB1 MDR1, P-gp Clotrimazole 6.7 Calcein AM MDR1 expressing LLC-PK1 cells Schwab, 2003
mouse_Abcb1a Mdr, Pgp, Pgy, Mdr3, P-gp, Abcb4, Mdr1a Clotrimazole 4.8 Calcein AM Mouse mdr1a expressing LLC-PK1 cells Schwab, 2003
mouse_Abcb1b mdr, Mdr1, Pgy1, Abcb1, Mdr1b, Pgy-1 Clotrimazole 3.5 Calcein AM Mouse mdr1b expressing LLC-PK1 cells Schwab, 2003
ABCB1 MDR1, P-gp Clotrimazole 16.6 Doxorubicin B16/F10 cells Bain, 1996
SLCO1B1 OATP1B1, OATP-C, OATP2, LST-1 Clotrimazole 9 Estradiol-17beta-glucuronide CHO-OATP1B1 Gui, 2008
SLCO1B1 OATP1B1, OATP-C, OATP2, LST-1 Clotrimazole 7.6 Estradiol-17beta-glucuronide CHO-OATP1B1 Gui, 2009
ABCB1 MDR1, P-gp Clotrimazole 29.92 Vinblastine MDR1-expressing LLC-PK1 cells Ekins, 2002

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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