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Clonidine

In Vitro Substrates

No substrate information.

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Inhibitor	IC50 (μM)	Ki (μM)	Substrate used	Cell System	Reference
SLC47A1	MATE1	Clonidine	8.09		1-methyl-4-phenylpyridinium (MPP+)	CHO-MATE1	Astorga, 2012
SLC47A2	MATE2K	Clonidine	54		1-methyl-4-phenylpyridinium (MPP+)	CHO-MATE2K	Astorga, 2012
SLC22A2	OCT2	Clonidine	6		1-methyl-4-phenylpyridinium (MPP+)	CHO-OCT2	Belzer, 2013
SLC22A1	OCT1	Clonidine	22.6		4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+)	HEK293-OCT1	Ahlin, 2008
SLC47A1	MATE1	Clonidine	33.3		4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+)	HEK293-MATE1	Wittwer, 2013
SLC22A1	OCT1	Clonidine	18.98		4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+)	HEK293-OCT1	Chen, 2017
SLC22A2	OCT2	Clonidine	0.68		Metformin	CHO-OCT2	Belzer, 2013
SLC22A3	OCT3	Clonidine		373	N-methylpyridinium	HRPE-OCT3	Wu, 2000
SLC22A1	OCT1	Clonidine	6.5		N-methylpyridinium	HEK293-OCT1	Muller, 2005
SLC22A2	OCT2	Clonidine	23		N-methylpyridinium	HEK293-OCT2	Muller, 2005
SLC22A3	OCT3	Clonidine	110		N-methylpyridinium	CHO-OCT3	Muller, 2005
SLC22A2	OCT2	Clonidine	16		N-methylpyridinium	HEK293-OCT2	Zolk, 2009
SLC22A2	OCT2	Clonidine	4.5		NBD-MTMA	CHO-OCT2	Belzer, 2013
SLC22A1	OCT1	Clonidine		0.55	Tetraethylammonium	HeLa-OCT1	Zhang, 1998
SLC22A1	OCT1	Clonidine	0.71		Tetraethylammonium	HeLa-OCT1	Bednarczyk, 2003

No drug-drug interaction information.