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Clofazimine

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

No substrate information.


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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
ABCB1 MDR1, P-gp Clofazimine 0.6 Daunorubicin NIH-3T3-G185 cells Wang, 2001
ABCC2 MRP2, cMOAT Clofazimine 10.4 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC3 MRP3 Clofazimine 21 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC4 MRP4 Clofazimine 44.5 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCB1 MDR1, P-gp Clofazimine 1.1 LDS-751 NIH-3T3-G185 cells Wang, 2001
ABCB1 MDR1, P-gp Clofazimine 1 Rhodamine 123 NIH-3T3-G185 cells Wang, 2001
ABCB11 BSEP Clofazimine 2.3 Taurocholate BSEP-expressing Sf9 vesicles Kis, 2009
ABCB11 BSEP Clofazimine 12.9 Taurocholate Sf9 cell membrane vesicles Morgan, 2013

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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