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Cholate

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Km (μM) Cell System Reference
SLC10A2 ASBT, SBAT2 33.3 COS1-ASBT Craddock, 1998
SLCO1B1 OATP1B1, OATP-C, OATP2, LST-1 11.4 HEK293-OATP1B1 Cui, 2001
SLC10A1 NTCP 12 HeLa-NTCP Ho, 2004
ABCC4 MRP4 14.8 MRP4-expressing V79 vesicles Rius, 2006

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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
SLC10A2 ASBT, SBAT2 Cholate 41.5 Taurocholate COS1-ASBT Craddock, 1998
SLC10A1 NTCP Cholate 5.3 Taurocholate HeLa-NTCP Kim, 1999

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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