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Chlorpromazine

In Vitro Substrates

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Km (μM)	Cell System	Reference
ABCB1	MDR1, P-gp	27.4	MDR1-expressing insect vesicles	Boulton, 2002

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Inhibitor	IC50 (μM)	Substrate used	Cell System	Reference
SLC22A1	OCT1	Chlorpromazine	27	4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+)	HEK293-OCT1	Ahlin, 2008
SLC22A1	OCT1	Chlorpromazine	52.3	4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+)	HEK293-OCT1	Ahlin, 2010
ABCC2	MRP2, cMOAT	Chlorpromazine	>133	Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
ABCC3	MRP3	Chlorpromazine	>133	Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
ABCC4	MRP4	Chlorpromazine	>133	Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
SLC22A2	OCT2	Chlorpromazine	14	N-methylpyridinium	HEK293-OCT2	Zolk, 2009
SLC22A2	OCT2	Chlorpromazine	2.6	NBD-MTMA	CHO-OCT2	Belzer, 2013
ABCB11	BSEP	Chlorpromazine	>133	Taurocholate	Sf9 cell membrane vesicles	Morgan, 2013
SLC22A1	OCT1	Chlorpromazine	4.3	Tetraethylammonium	HeLa-OCT1	Bednarczyk, 2003

No drug-drug interaction information.