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Cefotaxime

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

No substrate information.


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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
ABCC4 MRP4 Cefotaxime 24 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC2 MRP2, cMOAT Cefotaxime >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC3 MRP3 Cefotaxime >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
SLC22A11 OAT4 Cefotaxime 6150 Prostaglandin F2-alpha S2-OAT4 Khamdang, 2003
SLC22A6 OAT1 Cefotaxime 3130 Prostaglandin F2-alpha S2-OAT1 Khamdang, 2003
SLC22A7 OAT2 Cefotaxime 4680 Prostaglandin F2-alpha S2-OAT2 Khamdang, 2003
SLC22A8 OAT3 Cefotaxime 290 Prostaglandin F2-alpha S2-OAT3 Khamdang, 2003
ABCB11 BSEP Cefotaxime >133 Taurocholate Sf9 cell membrane vesicles Morgan, 2013

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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