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Bumetanide

In Vitro Substrates

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Km (μM)	Cell System	Reference
SLC22A11	OAT4	306	S2-OAT4	Hasannejad, 2004
SLC22A8	OAT3	1586	S2-OAT3	Hasannejad, 2004
SLC22A7	OAT2	7.52	OAT2-expressing oocytes	Kobayashi, 2005

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Inhibitor	IC50 (μM)	Substrate used	Cell System	Reference
ABCC3	MRP3	Bumetanide	>133	Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
ABCC4	MRP4	Bumetanide	>133	Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
SLC22A11	OAT4	Bumetanide	348	Estrone sulfate	S2-OAT4	Hasannejad, 2004
SLC22A8	OAT3	Bumetanide	0.75	Estrone sulfate	S2-OAT3	Hasannejad, 2004
SLC22A8	OAT3	Bumetanide	7.8	Estrone sulfate	OAT3-expressing oocytes	Elsby, 2011
SLC22A8	OAT3	Bumetanide	5.4	Methotrexate	OAT3-expressing oocytes	Elsby, 2011
SLC22A6	OAT1	Bumetanide	7.6	Para-aminohippurate	S2-OAT1	Hasannejad, 2004
SLC22A7	OAT2	Bumetanide	77.5	Prostaglandin F2-alpha	S2-OAT2	Hasannejad, 2004
ABCB11	BSEP	Bumetanide	>133	Taurocholate	Sf9 cell membrane vesicles	Morgan, 2013

No drug-drug interaction information.