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Benzbromarone

In Vitro Substrates

No substrate information.

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Inhibitor	IC50 (μM)	Substrate used	Cell System	Reference
ABCC4	MRP4	Benzbromarone	150	9-(2-phosphonomethoxyethyl)adenine (PMEA)	MRP4-expressing HEK293 vesicles	Reid, 2003
ABCC5	MRP5	Benzbromarone	150	9-(2-phosphonomethoxyethyl)adenine (PMEA)	MRP4-expressing HEK293 vesicles	Reid, 2003
SLCO2B1	OATP2B1, OATP-B	Benzbromarone	0.1	Dibromofluorescein	HEK293-OATP2B1	Unger, 2020
ABCC2	MRP2, cMOAT	Benzbromarone	41.6	Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
ABCC4	MRP4	Benzbromarone	17	Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
ABCC3	MRP3	Benzbromarone	>133	Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
ABCC6	MRP6	Benzbromarone	ND	N-ethylmaleimide S-glutathione	MRP6-expressing Sf9 vesicles	Ilias, 2002
ABCB11	BSEP	Benzbromarone	17.5	Taurocholate	Sf9 cell membrane vesicles	Morgan, 2013
SLC22A6	OAT1	Benzbromarone	3.14	Urate	HEK293-OAT1	Taniguchi, 2019
SLC22A8	OAT3	Benzbromarone	0.967	Urate	HEK293-OAT3	Taniguchi, 2019
SLC22A12	URAT1	Benzbromarone	~0.3	Uric acid	HEK293-URAT1	Yu, 2007
SLC22A12	URAT1	Benzbromarone	0.13	Uric acid	HEK293-URAT1	Uetake, 2010

No drug-drug interaction information.