| Transporter |
Synonyms |
Inhibitor |
IC50 (μM) |
Ki (μM) |
Substrate used |
Cell System |
Reference |
| SLC47A1 |
MATE1 |
Atropine |
6 |
| 1-methyl-4-phenylpyridinium (MPP+) |
CHO-MATE1 |
Astorga, 2012 |
| SLC47A2 |
MATE2K |
Atropine |
52 |
| 1-methyl-4-phenylpyridinium (MPP+) |
CHO-MATE2K |
Astorga, 2012 |
| SLC22A1 |
OCT1 |
Atropine |
3 |
| 1-methyl-4-phenylpyridinium (MPP+) |
HEK293-OCT1 |
Chen, 2017 |
| SLC22A2 |
OCT2 |
Atropine |
12.4 |
| 1-methyl-4-phenylpyridinium (MPP+) |
CHO-OCT2 |
Sandoval, 2018 |
| SLC22A1 |
OCT1 |
Atropine |
12.2 |
| 4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+) |
HEK293-OCT1 |
Ahlin, 2008 |
| SLC22A2 |
OCT2 |
Atropine |
1.4 |
| 4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+) |
CHO-OCT2 |
Sandoval, 2018 |
| ABCC2 |
MRP2, cMOAT |
Atropine |
>133 |
| Estradiol-17beta-glucuronide |
Sf9 cell membrane vesicles |
Morgan, 2013 |
| ABCC3 |
MRP3 |
Atropine |
>133 |
| Estradiol-17beta-glucuronide |
Sf9 cell membrane vesicles |
Morgan, 2013 |
| ABCC4 |
MRP4 |
Atropine |
>133 |
| Estradiol-17beta-glucuronide |
Sf9 cell membrane vesicles |
Morgan, 2013 |
| SLC22A5 |
OCTN2 |
Atropine |
| 4000 |
L-carnitine |
MDCKII-hOCTN2 |
Diao, 2009 |
| SLC22A2 |
OCT2 |
Atropine |
1.3 |
| Metformin |
CHO-OCT2 |
Sandoval, 2018 |
| SLC22A1 |
OCT1 |
Atropine |
1.2 |
| N-methylpyridinium |
HEK293-OCT1 |
Muller, 2005 |
| SLC22A2 |
OCT2 |
Atropine |
39 |
| N-methylpyridinium |
HEK293-OCT2 |
Muller, 2005 |
| SLC22A3 |
OCT3 |
Atropine |
466 |
| N-methylpyridinium |
CHO-OCT3 |
Muller, 2005 |
| SLC22A2 |
OCT2 |
Atropine |
2.3 |
| NBD-MTMA |
CHO-OCT2 |
Sandoval, 2018 |
| ABCB11 |
BSEP |
Atropine |
>133 |
| Taurocholate |
Sf9 cell membrane vesicles |
Morgan, 2013 |
| SLC22A2 |
OCT2 |
Atropine |
2 |
2.4 |
Tetraethylammonium |
S2-OCT2 |
Chiba, 2013 |
| SLC22A2 |
OCT2 |
Atropine |
3.4 |
| Tetraethylammonium |
CHO-OCT2 |
Sandoval, 2018 |
