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Aripiprazole

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

No substrate information.


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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
SLC47A1 MATE1 Aripiprazole 130 4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+) HEK293-MATE1 Wittwer, 2013
SLC47A2 MATE2K Aripiprazole >500 4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+) HEK293-MATE2K Wittwer, 2013
ABCC2 MRP2, cMOAT Aripiprazole >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC3 MRP3 Aripiprazole >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC4 MRP4 Aripiprazole >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCG2 BCRP, MXR Aripiprazole 3.5 Methotrexate BCRP membrane vesicles Nagasaka, 2012
ABCB1 MDR1, P-gp Aripiprazole 0.8 Rhodamine 123 MDR1 expressing L5178 cells Broccatelli, 2011
ABCB11 BSEP Aripiprazole >133 Taurocholate Sf9 cell membrane vesicles Morgan, 2013

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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