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Amprenavir

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

No substrate information.


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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
SLCO1B1 OATP1B1, OATP-C, OATP2, LST-1 Amprenavir 16.8 9.52 Atorvastatin HEK-OATP1B1 Karlgren, 2012
SLCO1B1 OATP1B1, OATP-C, OATP2, LST-1 Amprenavir 14.4 12.8 Cholyl-glycylamido-fluorescein (CGamF) CHO-OATP1B1 Annaert, 2010
SLCO1B3 OATP1B3, OATP8 Amprenavir 19.1 13.1 Cholyl-glycylamido-fluorescein (CGamF) CHO-OATP1B3 Annaert, 2010
SLCO1B3 OATP1B3, OATP8 Amprenavir 38 Estradiol-17beta-glucuronide HEK-OATP1B3 Chiou, 2014
ABCC2 MRP2, cMOAT Amprenavir >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC3 MRP3 Amprenavir >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC4 MRP4 Amprenavir >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCG2 BCRP, MXR Amprenavir 181 Pheophorbide A MDCK II-BCRP Weiss, 2007
ABCB11 BSEP Amprenavir 44.8 Taurocholate Sf9 cell membrane vesicles Morgan, 2013

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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